Furthermore, transcriptional inactivation of Sal-like protein 3 (SALL3) was found to be associated with aberrant methylation of other tumor-related genes and ten-eleven translocation (TET) family genes, as well as DNA methyltransferase 3 alpha (DNMT3A) levels, in HNSCC [12]. The gene discussed is DNMT3A; the disease is head and neck squamous cell carcinoma.