TGFB1 and cancer: Gene enrichment-based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the 34 interacting proteins for PDE6D revealed significant pathway enrichments associated with cancer including “MAPK signaling” (P = 0.00023), “Ras signaling” (P = 0.0011), and “TGFβ signaling” (P = 0.00623) (Figure S4B).