These insertions encompass residues from 762 to 775 (spatially located after the C-helix of the EGFR kinase domain) and represent a highly heterogeneous family of EGFR mutations, with over 64 unique variants described to date, with an estimated incidence of up to about 10% of all EGFR mutants in NSCLC [64,65,66,67]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.