XMD8-92-treated tumors demonstrated drastic downregulation of doublecortin-like kinase 1 (DCLK1) and several of its downstream targets, including c-MYC, KRAS, NOTCH1, ZEB1, ZEB2, SNAIL, SLUG, VEGFR1, VEGFR2, and pluripotency genes, via upregulation of tumor suppressor miRNAs let-7a, miR-144, miR-200a-c, and miR-143/145 [58]. Here, DCLK1 is linked to neoplasm.