In addition, knockdown of cytokine-induced apoptosis inhibitor 1 (CIAPIN1), an apoptosis inhibitor with no homology to apoptosis regulatory molecules of the Bcl-2 or caspase families, sensitizes K562 chronic myeloid leukemia cells to imatinib by regulating apoptosis-associated members via the NF-κB and ERK5 signaling pathway [120]. The gene discussed is CIAPIN1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.