Previous studies have revealed that BMSCs can migrate to the injured liver and differentiate to α-SMA+ myofibroblasts in liver fibrosis.27, 28, 29 Here we document the high expression of PDGFR-β on BMSCs in the fibrotic liver of MCDHF mice, and we identify the function of these PDGFR-β+ BMSCs, which is closely associated with liver fibrogenesis and angiogenesis. This evidence concerns the gene ACTA1 and Hepatic fibrosis.