PDGFRB and Hepatic fibrosis: For instance, during angiogenesis, endothelial cell-derived platelet-derived growth factor B recruits perivascular cells onto angiogenic blood vessels through the activation of PDGFR-β.21, 22, 23 Additionally, PDGFR-β plays a crucial role in the pathological processes of chronic liver diseases, and inhibition of PDGFR-β signaling by destruxin A5 represents an appealing target for the treatment of bile duct ligation-induced liver fibrosis.24