PDGFRB and cancer: lncMEG3 was first identified as a tumor suppressor in various cancers,41, 42, 43 and recent studies have highlighted the importance of lncMEG3 in angiogenesis and the maintenance of normal function of vascular endothelial cells.31, 32, 33 Gain-of-function studies have confirmed that lncMEG3 acts as an endogenous sponge to suppress the biological function of miR-26b-5p by a sequence-complementary mechanism and to increase PDGFR-β expression in BMSCs.