In order to verify if the altered mTOR and FoxO1 pathways could contribute to skeletal muscle atrophy in DM and T2DM patients i.e. those patients who showed insulin resistance, we analysed the correlation of mTOR, FoxO1, MuRF1 and Atrogin-1/MAFbx expressions with atrophy factors. The gene discussed is TRIM63; the disease is Insulin resistance.