Our results on the aberrant mTOR/FoxO1 pathways in DM muscles are in line with those observed by other authors that showed an abnormal mTORC1 signalling activation in HSALR mice and in human DM1 cells [33,54,55], and an increase in proteasome activity in DM2 muscle cells [18,56]. This evidence concerns the gene MTOR and myotonic dystrophy type 1.