When inflammasome-related genes expression was evaluated according to the clinical stages of dengue, a statistically significant decrease was found in the mRNA of NLRP1 (p< 0.05), NLRC4 (p< 0.01), caspase-1 (p< 0.01) IL-18 (p< 0.0001) and IL-1β (p< 0.05) in DWWS patients, compared with healthy controls (Fig 4). Here, IL18 is linked to dengue disease.