CASP1 and dengue disease: Here we found that the mRNA levels of NLRP1 (p = 0.0032), NLRC4 (p = 0.0026), caspase-1 (p = 0.0005), IL-18 (p< 0.0001) and IL-1β (p = 0.0179), were lower in dengue patients compared with healthy controls (Fig 3), however differences between NLRP3, AIM2 and ASC were not found.