MAPT and concussion: In a study enrolling 288 professional hockey players, tau levels increased significantly after brain concussion (4.5 [0.06 to 22.7] pg/mL vs. 10.0 [2.0 to 171) pg/mL, P<0.001), and presented higher diagnostic accuracy compared with other known biomarkers of brain injury, namely S-100B and NSE (AUC: tau = 0.80, S100 = 0.67, NSE = 0.55) [11].