Our data supports and corroborates conclusions drawn by Rai et al., which identified HIRA to play an important role in the intrinsic antiviral restriction of ΔICP0 HSV-1 [17], and emphasizes the importance of multiple histone chaperone complexes (Daxx/ATRX and HIRA/UBN1/CABIN1) in the spatiotemporal regulation of intrinsic immune defences during different phases of herpesvirus infection [29, 31, 79]. This evidence concerns the gene DAXX and Herpesviridae infectious disease.