In the biological distribution of 111In-labeled 3-arm (Table 2) and 4-arm DOTA-α-MSH (Table 3) and whole-body SPECT imaging (Fig 4), accumulation of 111In-labeled 4-arm DOTA-α-MSH was significantly higher than that of 111In-labeled 3-arm DOTA-α-MSH in B16-F1 melanoma. This evidence concerns the gene STAMBP and melanoma.