RARRES2 and colonic neoplasm: In analyses by colon cancer subtype, higher chemerin concentrations were associated with a greater risk of proximal colon cancer (HR, 3.97; 95% CI, 1.51-10.50; P for trend = .001 for the final multivariable-adjusted model for the highest chemerin quartile vs the lowest), whereas no pronounced elevated risk was observed for distal colon cancer (HR, 1.16; 95% CI, 0.49-2.75; P for trend = .52) (Table 2).