Second, chemerin is involved in the recruitment of immune cells at the site of infection and could have a role as a proxy marker of systemic immune response.47 In particular, a link between bacterial infection and CRC was recently suggested by an analysis of 4063 incident cases of CRC matched to 4063 controls from 10 prospective cohorts.48 In that study, serologic responses to Helicobacter pylori proteins, including virulence factors VacA and CagA, were associated with a greater risk of CRC. This evidence concerns the gene S100A8 and infection.