This analysis demonstrated that TMEM63C is expressed in podocytes of all glomeruli in healthy controls (Figure 5A,E), while patients with FSGS exhibit a significant decrease of TMEM63C expression (Figure 5B–E) with a global loss of glomerular TMEM63C in the majority of patients analyzed (Figure 5D–F). Here, TMEM63C is linked to focal segmental glomerulosclerosis.