APOE and atherosclerosis: Compared with control Apoe-/-LmnaLCS/LCS mice, fat-fed Apoe-/-LmnaLCS/LCSSM22αCre mice (but not Apoe-/-LmnaLCS/LCSLysMCre mice) had a higher atherosclerosis burden and aortic structural alterations (VSMC loss, adventitial thickening, and lipid accumulation in the media).