Even though the principal cause of death in Apoe-/-LmnaG609G/G609G and Apoe-/-LmnaLCS/LCSSM22αCre mice is different, both models showed evidence of plaque disruption and myocardial infarction [32], complications rarely seen in mice but typical of late stages of atherosclerosis in HGPS and non-HGPS individuals. This evidence concerns the gene APOE and myocardial infarction.