LMNA and Hutchinson-Gilford progeria syndrome: Although HGPS was first described at the end of the 19th century [1,2], the cause of the disease remained elusive until 2003, when Eriksson et al. [13] and De Sandre-Giovannoli et al. [14] reported that HGPS patients carry a heterozygous de novo point mutation in the LMNA gene.