Progerin-triggered VSMC death was accompanied by excessive lipid accumulation in the aortic wall, suggesting that increased retention of atherogenic LDLs may account, at least in part, for the early onset of atherosclerosis in Apoe-/-LmnaG609G/G609G and Apoe-/-LmnaLCS/LCSSM22αCre mice. Here, APOE is linked to atherosclerosis.