This immune response system includes signal transduction pattern recognition receptors and pathogen‐associated molecular patterns induced by selective or specific signal transduction pathways, such as PKR, p53, and phosphorylated retinoblastoma protein pathways.27 Such signal transduction pathways in tumor cells are often abnormal, leading to the replication and amplification of the virus in such tumor cells.28 The efficacy of OV treatment depends on the ability of the virus to replicate and spread. The gene discussed is EIF2AK2; the disease is neoplasm.