SNPH and amyotrophic lateral sclerosis: It was reported that ALS mutant SOD1 induced degradation of Miro1 in a Parkin‐dependent manner, which further inhibited anterograde axonal transport of mitochondria.89 The degradation of syntaphilin also contributes to the alteration of mitochondrial mobility in the early stages of fALS‐linked mice (Figure 2A,B).43 However, given the roles of Miro and syntaphilin in both anterograde and retrograde mitochondrial transport, further investigations are needed to address the selective defects of mitochondrial anterograde transport in some fALS models.