SNPH and amyotrophic lateral sclerosis: However, enhanced axonal motility by depletion of syntaphilin fails to slow the disease progression in hSOD1G93A mice.91 Instead, improved autophagy‐lysosomal functions by enhancing transport of late endosomes ameliorate ALS‐like phenotype.92 Given the mitochondrial dysfunction and autophagy defects in ALS,93, 94 it may be necessary to combine strategies correcting mitochondrial transport with drugs activating autophagy to improve the mitochondrial quality in ALS (Figure 2C).