FBN1 and Marfan syndrome: The highest number of VLP/Ps (n = 94) were reported in both MYBPC3 (MIM: 600,958; definitive for hypertrophic and dilated cardiomyopathies[HCM/DCM]) and FBN1 (MIM: 134,797; definitive for Marfan syndrome), accounting for 60% and 51% of the total reported findings for these genes, respectively (Table S1–S3).