Gene therapy using adeno‐associated virus 2 (AAV2) to deliver VEGF‐Trap achieved long‐term expression of VEGF‐Trap in vitro and in vivo.9 Animal studies have demonstrated that the growth of breast cancer and glioma can be inhibited by a single injection of AAV2‐VEGF‐Trap.9, 10 In this report, we aimed to evaluate the antitumor efficacy of AAV2‐VEGF‐Trap alone or combination with paclitaxel in a TNBC animal model. This evidence concerns the gene VEGFA and breast carcinoma.