CRP and obesity due to melanocortin 4 receptor deficiency: However, when all covariates elevated CRP-hs, TNF-α genotype, obesity and age were included into the statistical analyses, the impact of obesity (BMI ≥ 30 kg/m2) on the level of DNA damage was independent of other covariates (F = 69.41, p = 0.0000) and no significant interaction effect was observed.