We have been conducting mechanistic studies on lung tropic melanoma metastasis [1,2], and we have found that S100A8/A9, a heterodimer complex of S100A8 and S100A9 proteins [[3], [4], [5]], which are Ca2+ binding small proteins of about 10 KDa in molecular mass belonging to the S100 family, and its novel receptor, melanoma cell adhesion molecule (MCAM) play important roles in the metastasis [6,7]. This evidence concerns the gene IGKV1D-22 and melanoma.