TGFb/ID1 signals promote metastatic colonization via a MET, antagonizing TWIST1 EMT (Gupta et al., 2007; Stankic et al., 2013) in normoxic metastatic sites, but not in hypoxic primary tumor sites (Mohyeldin et al., 2010), where EMT is governed by SNAIL1 (Stankic et al., 2013). The gene discussed is TGFB1; the disease is neoplasm.