TWIST1 and neoplasm: This phenotype would have mesenchymal features, that would result as a downstream effect of the STAT3-RAS-MAPK-ERK-MYC pathway, regulating ID3/E47 interactions and promoting tumor cell migration and invasion (Bain et al., 2001) through expression of mesenchymal genes such as MMPs, SNAIL1, TWIST1, and PRRX1.