Analysis of 441 melanomas and 90 nevi showed low LIFr expression for all nevus stages, whereas the presence of this receptor starts to increase in dysplastic nevi, with significantly higher expression in primary melanomas (implantation), and even higher in metastatic melanomas (Guo et al., 2015), suggesting a striking correlation between LIF/LIFr expression and oncogenesis. This evidence concerns the gene LIFR and metastatic melanoma.