TWIST1 and neoplasm: TGFb/ID1 signals promote metastatic colonization via a MET, antagonizing TWIST1 EMT (Gupta et al., 2007; Stankic et al., 2013) in normoxic metastatic sites, but not in hypoxic primary tumor sites (Mohyeldin et al., 2010), where EMT is governed by SNAIL1 (Stankic et al., 2013).