This phenotype would have mesenchymal features, that would result as a downstream effect of the STAT3-RAS-MAPK-ERK-MYC pathway, regulating ID3/E47 interactions and promoting tumor cell migration and invasion (Bain et al., 2001) through expression of mesenchymal genes such as MMPs, SNAIL1, TWIST1, and PRRX1. This evidence concerns the gene PRRX1 and neoplasm.