This time course of pathological changes was highly coincidence with the dynamic of cardiac Dpep2 expression as shown in Figures 1C,D, in which Dpep2 expression was remarkably increased on day 3 and maintained at the high level from day 5 to day 7, further confirming that CVB3 infection could up-regulate the cardiac Dpep2 expression, and also suggesting that Dpep2 might be involved in the pathogenesis of CVB3-induced myocarditis. This evidence concerns the gene DPEP2 and myocarditis.