NFKB1 and myocarditis: In summary, our results revealed a novel inflammation inhibition effect of macrophage Dpep2 in the context of CVB3-induced myocarditis, and showed that in addition to being a dipeptidase, macrophage Dpep2 could also modulate cardiac inflammatory responses and alleviate CVB3-induced myocarditis by acting as a regulator of NF-κB inflammatory signaling pathway.