AZD7687 has shown to be more potent in vitro (0.01 μmol/L) in HuTu 80 (Human gastrointestinal tumor cell line) compared to human liver microsomes (Barlind_2012); the estimated in vivo potency in humans is also in very good agreement with the in vitro HuTu 80 value suggesting that the differences between in vitro and in vivo in man could be explained for differences in affinity toward DGAT1 in different organs. This evidence concerns the gene DGAT1 and digestive system neoplasm.