We found that hyperbilirubinemia (odds ratio [OR]: 38.6, 95% confidence of interval [CI]: 2.4–613.6) was independently associated with the occurrence of PICs, in addition to intraoperative blood transfusion (OR: 5.9, 95% CI: 1.1–33.2); elevated CRP level of 15 mg/dL or more, which was the median value of peak CRP levels within 7 days following esophagectomy in all cases (OR: 8.2, 95% CI: 2.0–33.8); and transthoracic esophagectomy (OR: 24.8, 95% CI: 3.4–180.3). This evidence concerns the gene CRP and Hyperbilirubinemia.