Similarly, no patients with cancer cell scores above the median (4.5) achieved total tumor regression (TRG1; Figure 2B) and the median cancer cell phospho-ERK score was significantly (p = 0.02) lower for TRG1 responders (2.25) than for patients who responded moderately to poorly (TRG3-5; 6.0). The gene discussed is MAPK1; the disease is cancer.