Nautiyal et al. investigated EGFR regulation of colon cancer stem-like cells (CD44, CD166 and ALDH-1 positive cells) and found EGFR inhibition by anti-EGFR mAb cetuximab diminished age-related increase of CD166 and ALDH-1 suggesting EGFR could have an important role in the regulation of colorectal CSC [54]. This evidence concerns the gene ALCAM and malignant colon neoplasm.