DNA analysis (copy number variations and mutation analysis) of the 12 studied genes (BRAF, NRAS, MAP2K1, MET, CDKN2A, CDK4, CDK6, CCND1, CCND2, CCND3, RB1, CTNNB1) (Supplementary Table 2) was performed in melanoma lesions from 63 patients before treatment (1 missing because of insufficient material). Here, CDK4 is linked to melanoma.