CD274 and neoplasm: For this purpose, compiled Tissue, Cell, Lymph and Cluster Scores were converted into a four-letter code (POLE Score) that characterizes intratumoral overall PD-L1 expression (P), cellular Origin of expressed PD-L1 (O), PD-L1 expression status in tumor-associated Lymph follicles (L) and the Enumerated local distribution of PD-L1+ cells (E) by single digits.