Supporting our hypothesis of local CD8+ T cell response suppression by TAM-associated PD-L1 expression, both Zhang et al. and Kleinovink et al. showed in murine models of PDAC and colon carcionoma that myoleid cells substantially contribute to tumor initiation, growth of established tumors and suppression of CD8+ T cell response via self and induction of tumor cell-associated PD-L1 expression [45, 46]. Here, CD274 is linked to neoplasm.