FCGR3B and Autoimmunity: FCGR2A-131R (25) and FCGR2B-232T (26) have been implicated in increased risk of systemic lupus erythematous, while FCGR3B HNA 1B and decreased copy number of FCGR3B have been associated with reduced immune complex clearance and increased risk of autoimmunity (25, 27).