Within the lung, CXCR6 is more highly upregulated on human bronchoalveolar lavage (BAL)-derived and lung T-lymphocytes than those in the peripheral blood, and increased expression of CXCR6 on lung CD8+ T-lymphocytes correlates with disease severity in chronic obstructive pulmonary disease (17–20). The gene discussed is CXCR6; the disease is chronic obstructive pulmonary disease.