To assess whether the phenotypes of reduced disease severity (Figure 2) and reduced lung Th1-cytokine responses (Figure 3D) seen in CXCR6-deficient mice were specific to chronic bacterial infection with M. tuberculosis, we also examined the requirement of CXCR6 for resistance to an acute viral challenge with influenza A, which generates a substantial and contrasting inflammatory response in the lungs. The gene discussed is CXCR6; the disease is bacterial infectious disease.