APOE and atherosclerosis: Overexpression of a key biosynthetic enzyme for SPMs (Shen et al., 1996; Serhan et al., 2003) called 15-lipoxygenase (15-LOX), in rabbits or transgenic 12/15-LOX-ApoE-/- mice led to a significant decrease in atherosclerosis (Shen et al., 1996; Serhan et al., 2003).