Human mutations in the protocadherin-19 (PCDH19) gene, which encodes for the PCDH19 protein, also cause early infantile epileptic encephalopathy, associated with intellectual disability and autistic features (Kolc et al., 2019), similar to Dravet syndrome. This evidence concerns the gene PCDH19 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.