In fact, we previously identified GCAP1 hub residues that, when mutated, were associated with retinal dystrophies (Marino and Dell'orco, 2016), namely: D100, which is the target of the D100E/G substitutions (Kitiratschky et al., 2009; Dell'orco et al., 2010; Nong et al., 2014); L84, which is the target of the L84F substitution (Kamenarova et al., 2013; Marino et al., 2015a); Y99, associated with the Y99C mutation (Payne et al., 1998; Sokal et al., 1998); E155, associated with the E155A and E155G mutations (Wilkie et al., 2001); I143, found to be mutated in I143T/N (Nishiguchi et al., 2004). The gene discussed is GUCA1A; the disease is inherited retinal dystrophy.