CD4 and neoplasm: The GBM microenvironment is a complex milieu that ultimately promotes tumour cell transcriptomic adaptability and disease progression.6 GBM cells secrete numerous chemokines, cytokines and growth factors that promote infiltration of various cells: astrocytes, pericytes, endothelial cells, circulating progenitor cells and a range of immune cells such as microglia, peripheral macrophages, myeloid-derived suppressor cells (MDSC), leukocytes, CD4+ T cells and Treg into the tumour.7–10 Some previous work underlined that immune infiltrate could be associated with GBM prognosis.