Ethanol intragastric administration induced gastric ulcer animal model used to explore whether andrographolide is critical to maintain gastric ulcer vascular homeostasis; Human umbilical vascular endothelial cells used to investigate whether PFKFB3 mediated glycolysis pathway in involved for andrographolide in regulating gastric ulcer development. This evidence concerns the gene PFKFB3 and gastric ulcer.