PIP4K2A and breast carcinoma: Moreover, aberration of PIP4K2A and PIP4K2B are frequently observed in solid tumors, including breast carcinomas and lung adenocarcinomas (Fig. S4; Emerling et al., 2013; Keune et al., 2013; Jude et al., 2015), regulating genes that are involved in cell cycle progression, epithelial–mesenchymal transition, and reactive oxygen accumulation and metabolism, ultimately affecting tumor growth.