Transduction with lentivirus expressing PIP4K2A wild-type (PIP4K2A) significantly inhibited cellular viability and cellular growth in PIP4K2A-transduced GBM cells compared to the control groups (Fig. 3, A and B; and Fig. S2 A), whereas shRNA-mediated knockdown of PIP4K2A increased the cellular growth of PIPK2A wild-type cells compared with the non-targeting shRNA control (Fig. S2, A–C). This evidence concerns the gene PIP4K2A and glioblastoma.