As both PIP4K2A and PTEN are located on chromosome 10, we cross-analyzed their copy number variations and mRNA expression levels using The Cancer Genome Atlas (TCGA) patient GBM specimens and discovered that most patients exhibited dual genomic deletions or low transcriptome levels whereas only a small subset of patients has either PIP4K2A or PTEN deletion alone (Fig. 1 F and Fig. S1, A and B). This evidence concerns the gene PTEN and glioblastoma.