Moreover, aberration of PIP4K2A and PIP4K2B are frequently observed in solid tumors, including breast carcinomas and lung adenocarcinomas (Fig. S4; Emerling et al., 2013; Keune et al., 2013; Jude et al., 2015), regulating genes that are involved in cell cycle progression, epithelial–mesenchymal transition, and reactive oxygen accumulation and metabolism, ultimately affecting tumor growth. Here, PIP4K2A is linked to lung adenocarcinoma.