This insight highlights the potential of functional screening to identify essential genes that evade detection by other genomic technologies and is reminiscent of the situation in alveolar rhabdomyosarcoma, another fusion‐driven soft‐tissue tumor in which the pathognomonic PAX3‐FOXO1 oncoprotein promotes tumorigenesis by dysregulation of YAP1 (Crose et al, 2014). The gene discussed is PAX3; the disease is alveolar rhabdomyosarcoma.