As other translocation‐related sarcomas, e.g., Ewing sarcoma, synovial sarcoma, or alveolar rhabdomyosarcoma, MLS genomes harbor few somatic mutations, underscoring the dominant role of FUS‐DDIT3 in MLS pathogenesis (Barretina et al, 2010; Crompton et al, 2014; Shern et al, 2014; Tirode et al, 2014; Trautmann et al, 2019). Here, DDIT3 is linked to alveolar rhabdomyosarcoma.