Increased cytoplasmic Ca2+ levels in muscle cells have been observed in a number of human neuromuscular disorders, including myotonic dystrophies, Duchenne muscular dystrophy, as well as in ColQ and slow-channel myasthenic syndromes [reviewed in Vallejo-Illarramendi et al. (2014), Engel et al. (2015)]. Here, COLQ is linked to Duchenne muscular dystrophy.