Bpifa1 has an independent role in otitis media; its deficiency predisposes Bpifa1 KO mice to late-onset otitis media (Bartlett et al., 2015), and Bpifa1 deficiency on a MecomJbo/+ background increases the severity of otitis media (Mulay et al., 2018), but in neither case is there any indication that deficiency of Bpifa1 predisposes to otitis media via a bulla cavitation defect. The gene discussed is BPIFA1; the disease is otitis media.