FBXO11 is a candidate otitis media gene in humans (see discussion in Bhutta et al., 2017a,b), and we report that the established otitis media mouse model Fbxo11Jf/+ (Hardisty-Hughes et al., 2006;Hardisty et al., 2003) has a bulla cavitation defect. The gene discussed is FBXO11; the disease is otitis media.