DNA methylation (5-methylcytosine—5mC) is the best characterized and most stable epigenetic modification [5], and recent epigenome-wide association studies (EWAS) have utilized the Illumina Infinium Human Methylation 450K microarray (450K array) to demonstrate robust and reproducible changes in DNA methylation at a number of loci in AD brain [6, 7], including the ANK1 gene. Here, ANK1 is linked to Alzheimer disease.