YAP inhibition disrupts tumor-stroma interaction and suppresses pancreatic cancer progression [65] whereas YAP activation induces the expression of cytokines which recruits immunesuppressive leukocytes such as MDSCs and TAMs [66], suggesting that YAP acts as a transcriptional driver that orchestrates the immunesuppressive microenvironment within pancreatic ductal adenocarcinoma (PDAC). Here, YAP1 is linked to familial pancreatic carcinoma.