Components of the ECM such as fibronectin, collagens, tenascins and laminins are secreted by both tumor and stromal cells and are organized and remodelled by a plethora of other proteins that align, cross-link, integrate or digest the deposited fibers by a complex network of signals to generate an extracellular matrix that is typical of and characterizes each tumor. The gene discussed is FN1; the disease is neoplasm.