We propose that ZL170 impairs the stemness of TNBC cells in vitro and in vivo not only by directly targeting CSC-TFs Nanog and Sox2 but also by targeting EMT-TFs Snail and Slug to inhibit EMT-conferred CSC characteristics, and thus reduces CSC-associated tumor metastasis, recurrence and chemoresistance in TNBC. Here, SOX2 is linked to neoplasm.