In the present study, we find that disruption of epithelial TGFβ and BMP pathways by ZL170 may create a suppressive stromal microenvironment characterized by decreased ECM deposition as well as impaired recruitment and proliferation of cancer-associated fibroblasts (CAFs), endothelial cells and immune cells, which in turn reduces epithelial tumor growth, invasion and metastasis. The gene discussed is TGFB1; the disease is cancer.