We called these cells “quick responders,” and, as shown in Fig. 2c, by investigating the expression of several proteins belonging to the NER system, we observed that they expressed a significant higher protein level of ERCC1 as compared to “slow responders.” Indeed, the complex ERCC1/XPF is necessary for the formation of the trabectedin-induced DNA-DSB and ERCC1 expression has already been associated with response to trabectedin in cancer patients [22, 23]. The gene discussed is ERCC4; the disease is cancer.