Among the cathepsins, cathepsin B was most often associated with changes of cellular properties, although there were also numerous reports about cathepsins L, X, and K. Cathepsins B and X were thus shown to be important in the epithelial to mesenchymal transition in two breast cancer cell lines, MCF7 and MDA-MB-231, which express low and high amounts of cathepsins, respectively. Here, CTSS is linked to breast carcinoma.