CD4 and viral infectious disease: This prediction could also be applicable to viruses known to establish latency in the hosts and reported to have sustained TEMRA, e.g., parvoviruses (B19 and PARV49), herpes simplex virus 1 (HSV-1) [52].Thus, CD45RA depletion will provide optimal benefit in the case of viral infections that rely on CD4+ T-cell function.