GRM2 and Anxiety: Studies using the mGluR2/3 agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) in mGluR2 knock-out and mGluR3 knock-out mice showed that, although mGluR3 plays a role in anxiety-related behaviors, most of the anxiolytic effects in non-social contexts rely on mGluR2 [89,90].