ERBB2 and breast carcinoma: Perhaps not too surprising then, the phase III KRISTINE trial [34] found that for neoadjuvant treatment of HER2-positive patients with localized, operable breast cancer combining T-DM1 with pertuzumab was inferior to a combination of trastuzumab, pertuzumab, and two chemotherapeutics (docetaxel and carboplatin) with regards to pathologic complete response.