One report stated that miR-1246 is oncogenic and that miR-1246 promotes cancer stemness by activating Wnt/β-actin signaling; the other report stated that miR-1246 is a tumor-suppresser and that miR-1246 inhibits cell proliferation of HCC by down-regulating nuclear factor I B (NFIB) [61,62]. Here, NFIB is linked to hepatocellular carcinoma.