Yukawa et al. showed that exosomes derived from HCC play an important role in the influence of the immune system and angiogenesis through expressed killer cell lectin-like receptor K1 (KLRK1 /NKG2D), an activating receptor for immune cells, and HSP70, a stress-induced heat shock protein associated with angiogenesis [42]. Here, KLRK1 is linked to hepatocellular carcinoma.