Interestingly, MET proto-oncogenes, receptor tyrosine kinase (MET), S100 calcium binding protein A4 (S100A4), S100A10, S100A11, caveolin 1 (CAV1) and CAV2 at high levels were included in highly malignant HCC cell-derived exosomes. This evidence concerns the gene CAV1 and hepatocellular carcinoma.