According to case-controlled studies comparing the genetic distribution of PRND gene polymorphisms in codons 26, 56, 132 and 174 and 3’ untranslated region (UTR) +28, these polymorphisms were involved in the susceptibility to scrapie, BSE and sporadic CJD in ruminants and humans [36,37,38,39,40]. Here, PRND is linked to scrapie.