Furthermore, the novel developed T-cell receptor-like mAB 8F4 binds with high affinity a combined epitope of the PR1/HLA-A*02 complex and induced complement-dependent cytolysis of AML blasts and Lin−CD34+CD38− leukemic stem cells, but not of normal leukocytes [140]. Here, TMEM37 is linked to acute myeloid leukemia.