Multiple HLA-A*02-restricted epitopes of PRAME e.g., VLDGLDVLL, SLYSFPEPEA, ALYVDSLFFL, and SLLQHLIGL have been described and showed spontaneous CD8+ T-cell reactivity in ALL, AML, and CML patients [135]. Here, CD8A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.