Additionally, a TCR-like CAR with specificity for the PR1/HLA-A*02 complex, on the basis of the 8F4 mAB, was constructed, and transduced CAR T cells were capable to kill leukemia cell lines and primary AML blasts in vitro in an HLA-A*02-dependent manner [142]. This evidence concerns the gene TMEM37 and acute myeloid leukemia.