MCOLN1 and hyperinsulinemic hypoglycemia, familial, 4: This notion is further supported by the studies in MCOLN1-deficient mice and drosophila, showing that transplantation of wild-type (WT) bone marrow cells into MCOLN1-deficient mice and reconstitution of WT MCOLN1 in hemocytes in mcoln1-deficient drosophila can rescue, at least in part, the motor deficiency (Walker and Montell, 2016, Venkatachalam et al., 2008).